Analyses of global parameter sensitivity. Global effects of parameters on model variables are investigated by simultaneously varying all 19 parameters within a range of one order of magnitude larger and smaller than baseline values. A random sample of each parameter is generated from the range with a uniform distribution; the sampling is performed 5,000 times to calculate parameter sensitivities. Sensitivity value is between 0 and 1; the larger the value, the more important a parameter is to the output of a variable.
Ray et al. BMC Systems Biology 2013 7:37 doi:10.1186/1752-0509-7-37