Open Access Highly Accessed Research article

Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity

Sara Martinez-Pasamar1, Elena Abad2, Beatriz Moreno1, Nieves Velez de Mendizabal3, Ivan Martinez-Forero4, Jordi Garcia-Ojalvo2 and Pablo Villoslada1*

Author Affiliations

1 Center of Neuroimmunology, Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Barcelona, Spain

2 Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

3 School of Medicine and Indiana Clinical and Translational Sciences Institute, Indiana University, Indianapolis, IN, USA

4 Hospital Pablo Tobón Uribe, Medellin, Colombia

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BMC Systems Biology 2013, 7:34  doi:10.1186/1752-0509-7-34

Published: 26 April 2013

Additional files

Additional file 1 Table S1:

Parameters of the model and initial conditions. Figure S1. B cell counts after anti-CD20 therapy. Percentage of B cells in the spleen (L-B spleen) and the CNS (L-B CNS) from two immunized animal per day are plotted along the duration of the experiment (30 days). Figure S2. Predictions of the effects of changes in the survival/death rate of T cell populations in the oscillatory dynamics of T cells. Graphs shows simulations of the effect of a 2-fold decrease in the cell death rate of Teff and Treg in the period of T cell population oscillations.

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