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Open Access Highly Accessed Research article

Modelling the widespread effects of TOC1 signalling on the plant circadian clock and its outputs

Alexandra Pokhilko14, Paloma Mas2 and Andrew J Millar13*

Author Affiliations

1 School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JH, UK

2 Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB-UB, Parc de Recerca UAB, Bellaterra (Cerdanyola del Vallés), 08193, BarcelonaSpain

3 SynthSys, University of Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh, EH9 3JD, UK

4 Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Meston Building, Aberdeen, AB24 3UE, UK

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BMC Systems Biology 2013, 7:23  doi:10.1186/1752-0509-7-23

Published: 19 March 2013

Additional files

Additional file 1: Figure S1:

The profiles of the main components of ABA signalling, simulated under 12 L:12D diel cycles. The daily changes in the levels of ABA-ABAR, active PP2C and SnRK2 are shown by black, blue and red lines, respectively. Figure S2. The change in the relative amplitude and period of LHY mRNA in constant light conditions measured under 10% increase and decrease of the model parameters of inhibition of target genes by TOC1 and ABA signalling to the clock. Figure S3. Relative changes in the peak expression levels of the clock genes at varied ABA values. Simulations were done under 12 L:12D conditions. Expression levels were normalized to the value in absence of ABA.

Format: PPTX Size: 61KB Download file

Open Data

Additional file 2: Table S1:

Optimal set of the model parameter values.

Format: XLS Size: 59KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data