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This article is part of the supplement: The International Conference on Intelligent Biology and Medicine (ICIBM): Systems Biology

Open Access Research

Potential metabolic mechanism of girls' central precocious puberty: a network analysis on urine metabonomics data

Linlin Yang12, Kailin Tang2, Ying Qi3, Hao Ye24, Wenlian Chen5, Yongyu Zhang3* and Zhiwei Cao126*

Author Affiliations

1 School of Life Science and Technology, Tongji University, Shanghai 200092, China

2 Shanghai Center for Bioinformation Technology, Shanghai 200235, China

3 Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

4 State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai 200237, China

5 State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

6 Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai 200021, China

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BMC Systems Biology 2012, 6(Suppl 3):S19  doi:10.1186/1752-0509-6-S3-S19

Published: 17 December 2012

Additional files

Additional file 1:

Supplementary methods. A detailed description of topological parameters, significant level and Euclidian distance involved in this paper.

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Additional file 2:

Table S1. Enrichment of CPP differential urine metabolites in the bow-tie structure of human metabolic network.

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Additional file 3:

Table S2. CPP differential urine metabolites' proximity to neuro-endocrine system.

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