Table 2

The proportions of enhancers that underwent selection based on mouse-rat alignments (neutral reference: intron sites)

Total

Under selectiona

Positively selectedb

Under selectiona/Total

Positively selectedb/Under selectiona

Positively selectedb/Total


HT

2475

1222

428

49.37%

35.02%

17.29%

FB

1159

748

83

64.53%

11.09%

7.16%

MB

1218

720

147

59.11%

20.41%

12.06%

LB

2470

1449

301

58.66%

20.77%

12.18%


FB: forebrain; MB: midbrain; LB: limb; HT: heart.

aA significantly unequal proportion of substituted sites were observed between enhancers and the intron sites of the neighboring gene by Fisher's exact test.

bEnhancers that underwent selection and had a higher substitution rate than the intron sites of the neighboring gene.

Liao and Weng BMC Systems Biology 2012 6(Suppl 2):S1   doi:10.1186/1752-0509-6-S2-S1

Open Data