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This article is part of the supplement: Selected articles from The 5th IEEE International Conference on Systems Biology (ISB 2011)

Open Access Research

On optimal control policy for probabilistic Boolean network: a state reduction approach

Xi Chen, Hao Jiang*, Yushan Qiu and Wai-Ki Ching*

Author affiliations

Advanced Modeling and Applied Computing Laboratory, Department of Mathematics, The University of Hong Kong, Hong Kong

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Citation and License

BMC Systems Biology 2012, 6(Suppl 1):S8  doi:10.1186/1752-0509-6-S1-S8

Published: 16 July 2012

Abstract

Background

Probabilistic Boolean Network (PBN) is a popular model for studying genetic regulatory networks. An important and practical problem is to find the optimal control policy for a PBN so as to avoid the network from entering into undesirable states. A number of research works have been done by using dynamic programming-based (DP) method. However, due to the high computational complexity of PBNs, DP method is computationally inefficient for a large size network. Therefore it is natural to seek for approximation methods.

Results

Inspired by the state reduction strategies, we consider using dynamic programming in conjunction with state reduction approach to reduce the computational cost of the DP method. Numerical examples are given to demonstrate both the effectiveness and the efficiency of our proposed method.

Conclusions

Finding the optimal control policy for PBNs is meaningful. The proposed problem has been shown to be <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/S1/S8/mathml/M1','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/S1/S8/mathml/M1">View MathML</a>. By taking state reduction approach into consideration, the proposed method can speed up the computational time in applying dynamic programming-based algorithm. In particular, the proposed method is effective for larger size networks.