Figure 4.

Star drugs and their neighbors. (A) The distribution of neighbor drug pairs of star drugs. The neighbor pairs of star drugs can be classified into two groups, according to whether they have similar ATC codes, or whether they are used as effective combinations. (B) Schematic view of the relationship between two neighbors d₁ and d₂ of a star drug. (C) The percentage of effective combinations within neighbor drug pairs with TS equal to or larger than a certain threshold. Blue and red lines represent the drug cocktail network and the average of 1000 randomly generated combination networks, respectively.