Figure 4.

Proposed metabolic network associating with increased oxidative stress during the developing of membranous nephropathy. C5b-9 attack, the attack from membranous protein complex C5b-9 on podocyte; ROS, reactive oxygen species; L, Low urine protein membranous nephropathy; H, High urine protein membranous nephropathy; S, serum; U, urine; Red box means that the metabolite in urine or serum of "H" group was increased significantly than "L" group.

Gao et al. BMC Systems Biology 2012 6(Suppl 1):S14   doi:10.1186/1752-0509-6-S1-S14