Poor input measurement. (A-B) Input reconstruction – simulated data for the species A, B and the input x. True time courses are denoted by continuous lines. Data points are subject to Gaussian noise with σ = 0.1. For the input, only 4 data points are provided. (A) Data representations are indicated as dashed lines, (B) solution trajectories after parameter estimation are shown as dashed lines. (C) Comparison of parameter distributions obtained from 1000 repetitions of data generation and parameter estimation for the variational and the fixed input approach.
Kaschek and Timmer BMC Systems Biology 2012 6:99 doi:10.1186/1752-0509-6-99