Table 2

Description of the mammalian circadian clock model state variables
State variable name Unit Description
MP nM Concentration of Per mRNA
BN nM Concentration of non-phosphorylated Bmal1 protein in the nucleus
MC nM Concentration of Cry mRNA
MB nM Concentration of Bmal1 mRNA
PC nM Concentration of non-phosphorylated Per protein in the cytosol
PCP nM Concentration of phosphorylated Per protein in the cytosol
PCC nM Concentration of non-phosphorylated Per-Cry protein complex in the cytosol
CC nM Concentration of non-phosphorylated Cry protein in the cytosol
CCP nM Concentration of phosphorylated Cry protein in the cytosol
PCCP nM Concentration of phosphorylated Per-Cry protein complex in the cytosol
PCN nM Concentration of non-phosphorylated Per-Cry protein complex in the nucleus
PCNP nM Concentration of phosphorylated Per-Cry protein complex in the nucleus
IN nM Concentration of inactive complex between Per-Cry and Clock-Bmal1 in the nucleus
BC nM Concentration of non-phosphorylated Bmal1 protein in the cytosol
BCP nM Concentration of phosphorylated Bmal1 protein in the cytosol
BNP nM Concentration of phosphorylated Bmal1 protein in the nucleus

The 16 state variables correspond to the 16 ODEs in the mammalian circadian clock model.

Tøndel et al.

Tøndel et al. BMC Systems Biology 2012 6:88   doi:10.1186/1752-0509-6-88

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