Table 3

Covariance matrix C for the Michaelis-Menten reaction system.

S

SE

P

E


S

1455.82 (1455.57)

61.35 (61.23)

33.46 (32.80)

-61.35 (-61.23)

SE

61.35 (61.23)

59.09 (59.07)

-4.36 (-4.43)

-59.09 (-59.07)

P

33.46 (32.80)

-4.36 (-4.43)

773.86 (773.41)

4.36 (4.43)

E

-61.35 (-61.23)

-59.09 (-59.07)

4.36 (4.43)

59.09 (59.07)


The convariance matrix C for the Michaelis-Menten reaction system. Reaction parameters were chosen to be k1 = 0.2 nMs-1, k2 = 4 nM-1s-1, k3 = 3 s-1, k4 = 1 s-1, k5 = 0.15 s-1. The system volume was 10-12 l. The covariances calculated using the LNA was compared with those obtained from simulation (values in brackets) using 104 time series generated using the Gillespie algorithm (Direct Method) in COPASI

Pahle et al. BMC Systems Biology 2012 6:86   doi:10.1186/1752-0509-6-86

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