Resolution:
## Figure 4.
(a) Pairs of points satisfying a threshold value ofd(seeMethods) greater then 0.2. Seven pairs (s = 7; connected by blue lines) are selected for the following steps. The green line
is the true functional representation of X_{2} versus v_{3}, which in an actual situation is not known. (b) Pairs in (a) are merged, based on the distances between points in each “node” and
the distances between two points in a pair. (c) Subgroups of pairs in (b) are merged. (d) If the value of v_{3} is known for X_{2} = 1 or for some other value. The entire cluster of lines is vertically shifted accordingly.
If small values of X_{2} are covered by the pairs, the shift is determined by the observation that a flux
is usually zero if the substrate concentration is zero. Here, the sum of errors between
the estimated points and corresponding points on the true green line is 0.0354.
Chou and Voit |