Resolution:
## Figure 11.
(a) The experimental concentration data (29 time points) were smoothed and interpolated
with a spline function, thereby yielding metabolite levels ofX_{3}at about 300 time points. These X_{3} values were put into 186 different bins with size 0.03. Among these, 54 bins have
at least two X_{3} values. (b) Graph of X_{4} values, corresponding to at least two X_{3} values in each of the X_{3} bins. Selection of s pairs with a threshold d of 0.3 (here s = 12; see Text) are selected. (c) Pairs in (b) are merged. (d) Resulting functional plot of X_{4}vs. v_{4}; the blue dots represent the dots in (c), while the red triangles represent the true
plot of X_{4}vs. v_{4} in the dynamic model; in reality, these would not be known. (e) Functional plot of X_{3}vs. v_{3} (blue dots), calculated from the blue dots in (d), and true values of X_{3} (red triangles) according to the dynamic model. (f) Confirmation that the total mass (represented as the number of 3-carbon units) does
not change appreciably over time.
Chou and Voit |