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Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug

Hee Sook Lee16, Taejeong Bae126, Ji-Hyun Lee126, Dae Gyu Kim1, Young Sun Oh1, Yeongjun Jang3, Ji-Tea Kim3, Jong-Jun Lee1, Alessio Innocenti4, Claudiu T Supuran4, Luonan Chen5, Kyoohyoung Rho3* and Sunghoon Kim12*

Author Affiliations

1 Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul, Korea

2 World Class University Program Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, 151-742, Korea

3 Information Center for Bio-pharmacological Network, Seoul National University, Suwon, Korea

4 Dipartimento di Chimica Laboratorio di Chimica Bioinorganica, University of Florence, Via della Lastruccia, 3, Rm. 188 Polo Scientifico, Sesto Fiorentino (Firenze), 50019, Italy

5 Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200233, China

6 Medicinal Bioconvergence Research Center, Advanced Institutes of Convergence Technology, Suwon, 443-270, Korea

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BMC Systems Biology 2012, 6:80  doi:10.1186/1752-0509-6-80

Published: 2 July 2012

Additional files

Additional file 1:

Supplementary figures and tables. Detailed Description of Shared neighborhood score algorithm and algorithm Validation. Detailed description of the algorithm including non-linear regression results for extracting connecting probability functions. And a list of inferred SCC drug candidates is included.References.

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