Simplified BAD pathway. Solid lines represent gene interactions detected by competition profiles using mRNA expression. Dashed lines indicate the physical interactions. The numbers beneath the gene names are p-values corresponding to the expression change between mutant p53 and wild type p53 samples. The numbers above lines are p-values for the change in the competition profile for two genes connected between mutant p53 and wild type p53 samples. The arrows inside the gene symbols indicate the trends of the mRNA expression of mutant p53 samples in respect to p53 wild type samples, though the change is not statistically significant.
Liu et al. BMC Systems Biology 2012 6:65 doi:10.1186/1752-0509-6-65