Table 3

Transcriptional regulators and predicted target genes

Regulator

newly predicted target genest


Before refinement

After refinement


SreA

sreA, hem13*

sreA


HapX

hapX

hapX


PacC

pacC, hem13


SrbA

srbA,hapX

srbA,hemA


For each regulator, newly predicted target genes are shown. A target gene is counted as "newly predicted" if it was predicted by the time series data without prior knowledge, or if it was predicted by prior knowledge based on the occurrence of transcription factor binding motif (source 3) and was found to be consistent with the gene expression data. The second column of the table lists the results after refining the model. Bold genes have been validated by Northern blots [37] (before refinement) or binding to SrbA (after refinement). The interaction marked with asterix was falsified.

Linde et al. BMC Systems Biology 2012 6:6   doi:10.1186/1752-0509-6-6

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