Inferred regulatory network before refinement of the prior knowledge. The node colour denotes the cluster the gene belongs to. An edge between two nodes represents an interaction; arrows are activations while bars are repressions. Green edge: based on measured kinetics, consistent with prior knowledge, and robust(found more than 50% in models based on randomized input time series data and cross-validation of prior knowledge); blue edge: not in prior knowledge, based on measured kinetics, and robust; Grey edge: predicted by the prior knowledge but contradicting time series data, not in the model.
Linde et al. BMC Systems Biology 2012 6:6 doi:10.1186/1752-0509-6-6