Additional file 6.
The IKK/NF-κB signaling causal network model. The full causal model is given (top), along with a schematic of the basic model architecture (middle). CHUK, IKBKB, and IKBKG act as inhibitors of NFKBIA, NFKBIB, and NFKBIE, which are in turn inhibitors of NFKB1, NFKB2, and RELA. The nodes used in the model are listed under each section. The nodes in bold represent nodes that have downstream gene expression measurables in the knowledgebase, and the number of measurables is given in the square brackets (because the same downstream may be found under multiple nodes, these 1227 downstream measurables correspond to 992 unique measurables). The notations used in the knowledgebase are as follows: “CHUK P@S” represents CHUK phosphorylated at serine (where the residue is given if known), “CHUK P@ST” represents CHUK phosphorylated at serine or threonine (the exact residue is unknown), “kaof(CHUK)” represents the kinase activity of CHUK, “CHUK:IKBKB” represents the complex of CHUK and IKBKB proteins, “IkappaB kinase complex Hs” represents an aggregate of the various IκB kinases (CHUK, IKBKB, and IKBKG) in Homo sapiens (Hs), “degradationof(NFKBIA)” represents the process of NFKBIA degradation, and “taof(NFKB1)” represents the transcriptional activity of NFKB1.
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Martin et al. BMC Systems Biology 2012 6:54 doi:10.1186/1752-0509-6-54