Topological nodes of down-regulated genes from HOS/143B and SaOS-2/LM7 models. Top significant pathways identified by MetaCore using all the topological significant nodes from the down-regulated genes from (A) HOS/143B and (B) SaOS-2/LM7 models. Four common significant pathways were identified in the top 10 pathways of the two models, namely the “Cytoskeleton remodeling/TGF/WNT”, “Cytoskeleton remodeling/Cytoskeleton remodeling”, “Cell adhesion_Chemokines and adhesion”, and “Cell adhesion_ECM remodeling”. All pathways shown are significant. Refer to Figure 1 legend for graph details.
Flores et al. BMC Systems Biology 2012 6:50 doi:10.1186/1752-0509-6-50