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Open Access Highly Accessed Research article

Identifying co-targets to fight drug resistance based on a random walk model

Liang-Chun Chen2, Hsiang-Yuan Yeh1*, Cheng-Yu Yeh2, Carlos Roberto Arias2 and Von-Wun Soo12*

Author Affiliations

1 Department of Computer Science, National Tsing Hua University, HsinChu 300, Taiwan

2 Institute of Information Systems and Applications, National Tsing Hua University, HsinChu 300, Taiwan

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BMC Systems Biology 2012, 6:5  doi:10.1186/1752-0509-6-5

Published: 19 January 2012

Additional files

Additional file 1:

The functional enrichment analysis of the genes treated by INH and ETA using David toolkit with p-value < 0.05 and FDR < 0.25. File name: additionalfile_1.pdf. We do the functional enrichment analysis of the genes in the drug resistance network treated by INH and ETA using DAVID toolkit. The first column denotes the functional terms. The second and third columns denote the p-value and FDR values. The last column "Cum(exp)" gives the cumulative expression value of the genes annotated in the functional term.

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Open Data

Additional file 2:

Known genes related to the drug response and resistance under INH and ETA treatment. File name: additionalfile_2.pdf. We list the drug response and resistance genes which have received considerable attentions from public literature.

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Open Data