Table 1

Metabolic fluxes in the network model used for data simulation
Flux Wild type (WT) PC cells (PYC)
Gluc.ext → G6P 1.00 1.00
G6P → R5P + CO2 0.29 0.08
GAP → Pyr 1.88 1.93
Pyr → Lac 0.95 0.30
OAC + AcCoA → AKG + CO2 0.89 1.88
Pyr + CO2 → OAC 0.00 0.84
Mal → OAC 0.89 1.10
Mal → Pyr + CO2 0.15 1.11

Fluxes were taken from Henry et al. and were normalized to glucose uptake. Fluxes are shown for wild-type HEK-293 cells (WT) and HEK-293 cells expressing yeast pyruvate carboxylase (PYC).

Crown et al.

Crown et al. BMC Systems Biology 2012 6:43   doi:10.1186/1752-0509-6-43

Open Data