FBrAtio predictions of solvent production using the iCAC490 model and fixed ratios. The model was simulated given (i) a glucose uptake rate of , (ii) varied SPF, (iii) constraints listed in Table 1, (iv) unidirectional acetate and butyrate secretion by diffusion, (v) f (rTHL): f (rPTA) = 2, (vi) f (rTHL): f (rAAD_1) = 10, (vii) f (CO2export): f (CO2 conversion) = 5, (viii) f (rPFO): f (rLDH) = 10, (ix) f (rCoAT, butrate): f (rCoAT, acetate) = 0.63, and (x) constant f (rCoAT): f (rBHBD) flux ratios of 1, 0.5, 0.1, and 0.01. The following curves are shown: acetone (cyan), butanol (red), and ethanol (green).
McAnulty et al. BMC Systems Biology 2012 6:42 doi:10.1186/1752-0509-6-42