FBrAtio results of wild-type metabolism using iCAC490. The model was simulated model given (i) a glucose uptake rate of 10 , (ii) varied SPF, (iii) constraints listed in Table 1, (iv) unidirectional acetate and butyrate secretion by diffusion, and (v) f (rTHL) f (rPTA) = 2, (vi) f (rTHL): f (rAAD_1) = 10, (vii) f (CO2export): f (CO2conversion) = 5, (viii) f (rPFO): f (rLDH) = 10, (ix) f (rCoAT, butyrate):f (rCoAT, acetate) = 0.63. Results qualitatively fit wild-type metabolism.
McAnulty et al. BMC Systems Biology 2012 6:42 doi:10.1186/1752-0509-6-42