Table 1

GO terms enriched among HFC control (see Additional File 4, Table S2 for complete list of GO terms)

ENRICHED HAPLOINSUFFICIENT SET


GO ID

GO term

Ontology

Number of genes

FDR


GO:0005840

ribosome

CC

287

3.55E-018


GO:0030880

RNA polymerase complex

CC

31

6.83E-016


GO:0055029

nuclear DNA-directed RNA polymerase complex DNA-directed RNA polymerase II, core

CC

31

6.83E-016


GO:0005665

DNA-directed RNA polymerase II, core complex

CC

12

3.51E-014


GO:0016591

DNA-directed RNA polymerase ll, holoenzyme

CC

70

4.70E-012


GO:0032991

Macromolecular complex

CC

1538

4.22E-010


GO:0005736

DNA-directed RNA polymerase I complex

CC

14

4.23E-006


GO:0005832

chaperonin-containing T-complex

CC

11

1.57E-005


GO:0005666

DNA-directed RNA polymerase III complex

CC

17

2.18E-005


GO:0032200

telomere organization and biogenesis

BP

260

4.25E-005


GO:0042254

ribosome biogenesis and assembly

BP

334

9.79E-005


GO:0000119

mediator complex

CC

21

0.000265


GO:0005838

proteasome regulatory particle

CC

20

0.014216


GO:0030528

transcription regulator activity

MF

335

0.014216


GO:0004175

endopeptidase activity

MF

77

0.027946


ENRICHED HAPLOPROFICIENT SET


GO ID

GO term

Ontology

Number of genes

FDR


GO:0007049

cell cycle

BP

552

0.002534


GO:0051320

S phase

BP

20

0.003251


GO:0006260

DNA replication

BP

151

0.010963


GO:0015932

nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity

MF

13

0.017113


GO:0000082

G1/S transition of mitotic cell cycle

BP

52

0.023716


GO:0005669

transcription factor TFIID complex

CC

14

0.034692


GO:0005685

snRNP U1

CC

15

0.035741


GO:0051052

regulation of DNA metabolic process

BP

41

0.043266


GO:0016020

membrane

CC

1592

0.044202


GO:0005991

trehalose metabolic process

BP

10

0.050603


Pir et al. BMC Systems Biology 2012 6:4   doi:10.1186/1752-0509-6-4

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