Table 1

Experimental conditions used for validation
Reference Gene KOs Media conditions
BioloMICS [16] 46 different carbon sources
Thevenieau,2007 [10] 15 gene KOs YNBD, YNBO, YNBC10, YNBC16, YNBT
T van den Temple, 2000 [17] Lactose, D-Galactose
Jardon, 2008 [18] FBP1 YNBD, Ethanol, Glycerol, Acetate
Flores, 2005 [19] PYC1, ICL1 YNBD, Ethanol, Aspartate, Glutamate
Yamagami, 2001 [20] PAT1 YNBC10, YNBD, Glycerol
Haddouche (PC) [21] ACL1 YNBD, YNBO
Kabran, 2010 [22] ICL1, MLS1, CIT2 Acetate, YNBO, YNBD
Beopoulos, 2008 [23] GUT2, POX1-6 YNBD, Glycerol, YNBO
Jiménez-Bremont, 2001 [24] OCD1 YNBD, YNBD + putrescine
Cheon, 2003 [25] TRP1 YNBD, YNBD + tryptophane

Literature sources used for validation of the Y. lipolytica model. Overall, 60 different media conditions were tested. Gene knockouts were assessed for 29 different Y. lipolytica gene loci, in 152different experiments. Only those cases where evident growth/no growth was observed were included in this analysis.

Loira et al.

Loira et al. BMC Systems Biology 2012 6:35   doi:10.1186/1752-0509-6-35

Open Data