Additional file 1.

Table S1 Manual curation of lost reactions. In many cases, orthology results fail to associate a target gene to an enzyme-coding gene in the scaffold model, suggesting that the reaction is absent. Each of these predictions were manually reviewed, where a reaction was confirmed as being absent (‘Lost’), or was upheld (‘Retained’) when empirical evidence was available. Genes for which no ortholog could be found are

in the gene association column.

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Loira et al. BMC Systems Biology 2012 6:35   doi:10.1186/1752-0509-6-35