Additional file 1.

Table S1 Manual curation of lost reactions. In many cases, orthology results fail to associate a target gene to an enzyme-coding gene in the scaffold model, suggesting that the reaction is absent. Each of these predictions were manually reviewed, where a reaction was confirmed as being absent (‘Lost’), or was upheld (‘Retained’) when empirical evidence was available. Genes for which no ortholog could be found are

    underlined
in the gene association column.

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Loira et al. BMC Systems Biology 2012 6:35   doi:10.1186/1752-0509-6-35