Table 1 |
|||
| Summary of GRN modules | |||
| Index | Size | Main regulators | Target gene functions |
| 1 | 419 | RUNX3, RUNX2, POU2AF1, POU2F2, FLI1, BHLHB3, PRDM1 |
Immune response, Plasma membrane, Cell activation |
| 2 | 328 | HAND2, TCF4, FOXF1, FOXF2, ARID5B, FOXL1 |
Extracellular region, Cell adhension |
| 3 | 270 | miR-150, miR-142, miR-155, miR-181a, miR-342, miR-27a, miR-146a, miR-199a, miR-214, HNF4A |
Mitochondrion, Oxidation reduction, Mitochondrial envelope |
| 4 | 152 | AR, miR-127, miR-377, miR-323, miR-299, miR-221, miR-433, miR-376a, miR-136, miR-18a, miR-296, miR-154, miR-431, miR-382, miR-369, miR-200b |
Oxidation reduction, Cofactor metabolic process, Steroid metabolic process |
| 5 | 103 | NR1I3, NR1I2, ESR1 |
Oxidation reduction, Microsome, Fatty acid metabolic process |
| 6 | 75 | E2F1, E2F7 |
Cell cycle, Mitosis, Chromosome, Nuclear lumen |
| 3, 4, 5 | 525 | NR1I3,miR-150, miR-142, miR-155, miR-181a, AR, NR1I2, miR-342, miR-27a, miR-146a, HNF4A, miR-199a, miR-218, miR-214, miR-127, miR-132, ESR1, miR-377, SOX4, miR-323, miR-299, miR-221, miR-23a |
Mitochondrion, Oxidation reduction, Cofactor binding, |
Regulators are sorted by the number of targets. Regulators that regulate more than 80 % of genes in each module are listed. Gene Ontology enrichment was applied by DAVID to find common functions of genes. Size of each module corresponds to the number of nodes. The detailed enrichment results can be found in Additional File 2.
Gu et al. BMC Systems Biology 2012 6:32 doi:10.1186/1752-0509-6-32
