Metabolic network analysis and the prediction of high-priority targets and drugs. The pipeline for the prioritization of drug and drug targets against L. major (MetDP) is based on an underlying metabolic network. This framework enables the hypothesized description of a mechanism of action for the drugs identified. The figure highlights specific prioritized targets (singly lethal or lethal in combination) and associated drugs. Compound structures were obtained from PubChem database.
Chavali et al. BMC Systems Biology 2012 6:27 doi:10.1186/1752-0509-6-27