Resolution:
## Figure 9.
Comparison with D-optimal design. This figure compares our set-based experimental design to FIM D-optimal design when using measurements that are characterized
by Gaussian distributions. (a) Figure illustrating different possible Gaussian distributions
for each of the three original measurement sample times (t_{1 }= 2, t_{2 }= 4 and t_{3 }= 6). The three distributions for each sample time are characterized by left shifted,
center shifted, and right shifted means. (b) Time index of predicted time points given
the number of additional measurements that can be made. The figure shows a comparison
of time point selection for the following: solid squares--set-based method, circle
, triangle and diamond . (c-d) Parameter estimations after adding one or two additional data measurements,
respectively; black dot--*, solid black line--set-based method, dashed black line solid grey line , dashed grey line . These results show the importance of accurate distribution characterization when
designing experiments using the FIM.
θMarvel and Williams |