Figure 4.

Parameter space intersection. This figure shows the estimated parameter uncertainty assuming a candidate measurement at t2 was added (<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/21/mathml/M57','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/21/mathml/M57">View MathML</a>, dark grey boxes) and the estimated parameter uncertainty assuming a candidate measurement at t6 was added (<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/21/mathml/M58','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/21/mathml/M58">View MathML</a>, light grey boxes). The black boxes show the brute-force combination of <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/21/mathml/M57','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/21/mathml/M57">View MathML</a> and <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/21/mathml/M58','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/21/mathml/M58">View MathML</a>. It is clear that the intersection of <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/21/mathml/M58','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/21/mathml/M58">View MathML</a> and <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/21/mathml/M58','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/21/mathml/M58">View MathML</a> is equivalent to the brute-force combination.

Marvel and Williams BMC Systems Biology 2012 6:21   doi:10.1186/1752-0509-6-21
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