Table 2

Z-scores of each network properties for regulatory motifs

Motif

Single-regulation

Co-regulation

Crosstalk


Regulator (s)

TF

miR

TF

miR

TF-miR

TF

miR

TF-miR


Degree

1.52

1.29

1.95

0.72

0.83

2.35

1.80

1.59


Closeness

1.55

1.86

2.02

1.22

1.26

2.45

2.73

2.12


Density

2.31

3.88

1.60

0.96

1.28

13.74

4.33

5.27


Clique level

1.51

1.46

1.53

1.19

1.00

2.14

2.02

1.63


Path length

-15.58

-24.10

-10.25

-6.66

-7.52

-21.27

-38.25

-50.47


*For single-regulation motifs, there are two types of regulators, TF and miRNA (miR). For co-regulation and crosstalk motifs, there are three types of regulators, TF-TF, miRNA-miRNA, and TF-miRNA. Here, we used TF and miR to represent TF-TF and miRNA-miRNA respectively. Path length represents the characteristic path length of the gene set.

Lin et al. BMC Systems Biology 2012 6:18   doi:10.1186/1752-0509-6-18

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