Intracellular concentrations of metabolites from the tricarboxylic acid pathway, pentose-phosphate pathway and storage carbohydrate metabolism. Malate (Mal) and citrate (Cit) from the TCA pathway; sedoheptulose-7-phosphate (S7P) from the PPP; trehalose-6-phosphate (T6P) as a precursor of storage carbohydrates. Samples were taken during sinoidal temperature cycles (△), linear temperature shifts from 30°C (○) or 12°C (⋄) and from batches at different temperatures (□). Error bars refer to the standard error of the averages of at least two duplicate samples and two independent experiments. The different colors indicate the temperature of the culture at the time of sampling.
Cruz et al. BMC Systems Biology 2012 6:151 doi:10.1186/1752-0509-6-151