Figure 3Figure 3.

Clustering of time-resolved fractional appearance profiles. Shown are the fractional appearance profiles of reactions over time. Under both (A) cold and (B) heat shock, the selected reactions group into 9 clusters. Enzyme names discussed in the text are given. A complete list of all enzyme names is given in the Additional file 1: Table S3. In both stresses clusters 7 and 9 represent metabolic reactions that are constantly active, most of them crucial for viability. All other clusters represent reactions that undergo (de)activation and are likely involved in stress response. Note: For better visualization, identical profiles are slightly shifted. Reference value is given by the profile appearing on the bottom.

Töpfer et al. BMC Systems Biology 2012 6:148   doi:10.1186/1752-0509-6-148
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