Table 3

Parameter estimations of the branched pathway model using noise-free data with X3 missing
Simultaneous method Incremental method
<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/142/mathml/M22','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/142/mathml/M22">View MathML</a> min ΦS min ΦC min ΦS
CPU time (sec) 85.03 h 4002.01 ± 696.11 1404.22 ± 120.71 445.47 ± 35.94
eSSM GO iterations 308 365 ± 91 67 ± 10 48 ± 10
Parameter error (%) 71.90 43.50 ± 2.34 68.85 ± 4.57 40.47 ± 0.59
ΦC
    4.54 × 10
    -3
6.46 × 10-3 ± 4.08 × 10-4
    3.38 × 10
    -3
 ± 1.14 × 10-4
5.94 × 10-3 ± 3.23 × 10-5
ΦS 1.03
    2.99 × 10
    -2
 ± 3.82 × 10-4
8.32 × 10-2 ± 4.04 × 10-3
    2.94 × 10
    -2
 ± 2.77 × 10-6

a. Only one out of five runs completed with a relative improvement of the objective function below 1% between iterations. The rest did not converge within the 5-day time limit after iterating for 471, 435, 863 and 786 times. The corresponding ΦC at termination were 4.99× 10-2, 4.92 × 10-2, 1.17 × 10-2 and 1.57 × 10-2, respectively.

Jia et al.

Jia et al. BMC Systems Biology 2012 6:142   doi:10.1186/1752-0509-6-142

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