Table 1

Parameter estimations of the branched pathway model using noise-free data
Simultaneous method Incremental method
<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/142/mathml/M16','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/142/mathml/M16">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/142/mathml/M17','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/142/mathml/M17">View MathML</a> min ΦC min ΦS
CPU time (sec) a 56.00 h 620.81 ± 64.30 95.95 ± 11.09 1.56 ± 0.19
eSSM GO iterations 323 4390 ± 391 14 ± 4 10 ± 2
Parameter error (%) 49.10 36.91% ± 1.09 21.56% ± 7.57 × 10-2 36.85% ± 6.48 × 10-3
<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/142/mathml/M18','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/142/mathml/M18">View MathML</a>
    4.54 × 10
    -3
6.54 × 10-3 ± 5.20 × 10-5
    4.03 × 10
    -3
 ± 6.22 × 10-8
6.00 × 10-3 ± 5.05 × 10-7
<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/142/mathml/M19','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/142/mathml/M19">View MathML</a> 7.01 × 10-2
    2.72 × 10
    -2
 ± 1.09 × 10-5
3.92 × 10-2 ± 9.86 × 10-6
    2.76 × 10
    -2
 ± 4.46 × 10-10

a. CPU time was based on a workstation with dual Intel Quad-Core 2.83 GHz processors.

b. Only one out of five runs completed with a relative improvement of the objective function below 1% between iterations. The rest did not converge within the 5-day time limit after iterating for 583, 989, 777, and 661 times. The corresponding ΦC at termination were 4.85× 10-2, 1.39 × 10-2, 1.75 × 10-2 and 3.75 × 10-2, respectively.

c. Mean value ± standard deviation out of five repeats.

d. Root mean square error of model predictions, where the underlined value refers to the objective function of the minimization.

Jia et al.

Jia et al. BMC Systems Biology 2012 6:142   doi:10.1186/1752-0509-6-142

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