Table 3

Potency of 5-LO inhibitors in whole blood from control (Normal) and asthmatic human volunteer[18]
CONTROL ASTHMATICS
IC50 (nM) IC80 (nM) IC50 (nM) IC80 (nM)
Experim. Model Experim. Model Experim. Model Experim. Model
Zileuton 850 ± 220 860 2270 ± 710 3330 1080 ± 220 860 2520 ± 1010 3270
PF-4191834 120 ± 10 125 300 ± 20 518 180 ± 20 143 390 ± 50 550

Karelina et al.

Karelina et al. BMC Systems Biology 2012 6:141   doi:10.1186/1752-0509-6-141

Open Data