Table 2

Potency of 5-LO Inhibitors in “LOS” model at different peroxide concentrations
Peroxide concentration (μM) IC50 for inhibition by Zileuton (nM) IC50 for inhibition by PF-4191834(nM)
For LTA4 For 5oxoETE For LTA4 For 5oxoETE
0 980 962 122 125
5* 860 1145 125 129
10** 860 1410 143 146
100 1450 12670 290 300

*- corresponds to healthy subjects.

** - corresponds to asthmatic subjects.

Karelina et al.

Karelina et al. BMC Systems Biology 2012 6:141   doi:10.1186/1752-0509-6-141

Open Data