Table 2

Summary of the reactions and parameter values used in the model
Reaction Parameter Value Units
Cholesterol intake k1 1 mg/day
Bile salt release k2 6 mg/day
Hepatic return of bile salts k3 4.29 mg/day
Bile salt excretion k4 8.56 × 10-1 mg/day
Bile salt synthesis k5 2.66 mg/day
Cholesterol absorption k6 5.29 × 10-4 mg/day
Cholesterol excretion k7 5.29 × 10-4 mg/day
Intestinal Nascent HDL synthesis k8 5 × 10-4 mg/day
Hepatic cholesterol storage k9 1 mg/day
Release of stored Hepatic cholesterol k10 5.998 mg/day
Hepatic Nascent HDL Synthesis k11 5 × 10-2 mg/day
VLDL cholesterol formation k12 1.6 × 10-2 mg/dL/day
Synthesis of hepatic LDL receptors khrs 100 number/day
Hepatic LDL receptors degradation k13 1 × 10-3 number/day
VLDL cholesterol hepatic reuptake k14 4.96 × 10-3 mg/dL/day
IDL cholesterol formation k15 4.3 × 10-1 mg/dL/day
IDL cholesterol hepatic reuptake k16 5.4 × 10-2 mg/dL/day
LDL cholesterol formation k17 3.8 × 10-1 mg/dL/day
Hepatic LDL receptors uptake of LDL-cholesterol k18 6.80 × 10-2 mg/dL/day
Hepatic receptor independent uptake of LDL-cholesterol k19 5.0 × 10-3 mg/dL/day
Peripheral LDL receptors uptake of LDL-cholesterol k20 6.75 × 10-3 mg/day/day
Peripheral independent uptake of LDL-cholesterol k21 5.0 × 10-6 mg/dL/day
Synthesis of peripheral LDL receptors kprs 100 number/day
Peripheral LDL receptors degradation k22 1 × 10-2 number/day
Peripheral cholesterol storage k23 1.75 × 10-2 mg/day
Release of stored peripheral cholesterol k24 1.07 × 10-1 mg/day
Peripheral steroid production k25 5 × 10-4 mg/day
HDL cholesterol formation k26 1.5 × 10-5 mg/dL/day
CETP mediated transfer of cholesterol to VLDL from HDL k27 10 × 10-3 mg/dL/day
CETP mediated transfer of cholesterol to LDL from HDL k28 1 × 10-3 mg/dL/day
Reverse cholesterol transport k29 5.0 × 10-2 mg/dL/day
Maximum rate of intestinal cholesterol synthesis ICSmax 1 × 102 mg/day
Intestinal cholesterol synthesis threshold ICSt 3.120 × 102 mg/day
Sensitivity of intestinal cholesterol synthesis IS 5 Fitting parameter
Maximum rate of biliary cholesterol release BCRmax 2 × 103 mg/day
Biliary cholesterol release threshold BCRt 5.55 × 104 mg/day
Sensitivity of the feedback equation for biliary cholesterol BS 5 Fitting parameter
Maximum rate of hepatic cholesterol synthesis HCSmax 5 × 102 mg/day
Sensitivity of hepatic cholesterol synthesis HS 5 Fitting parameter
Hepatic cholesterol synthesis threshold HCSt 9.39 × 104 mg/day
Maximum rate of peripheral cholesterol synthesis PCSmax 5 × 102 mg/day
Peripheral cholesterol synthesis threshold PPCt 8.0342 × 104 mg/day
Sensitivity of peripheral cholesterol synthesis PCSS 5 Fitting parameter

Mc Auley et al.

Mc Auley et al. BMC Systems Biology 2012 6:130   doi:10.1186/1752-0509-6-130

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