Table 1

List of species, their abbreviations and their initial values
Dietary Species Symbol Initial Value
Dietary cholesterol DC 304 mg
Intestinal Species
Intestinal cholesterol IC 3150 mg
Intestinal bile salts IBS 467 mg
Intestinal cholesterol synthesis ICS 0 (Source Species)
Intestinal nascent high density lipoprotein synthesis INHDLS 0 (Source species)
Excreted Species
Excreted cholesterol EC 0
Excreted bile salts EBS 0
Hepatic Tissue Species
Hepatic cholesterol synthesis HCS 0 (Source Species)
Hepatic nascent HDL synthesis HNHDLS 0 (Source Species)
Hepatic bile salt pool HBS 400 mg
Hepatic free cholesterol HFC 60000 mg
Hepatic low density lipoprotein receptors HLDLRs 100 (Theoretical value to represent the number of hepatic LDL receptors )
Hepatic low density lipoprotein receptor synthesis HLDLRsS 600 (Source species)
Hepatic LDL receptors degradation HLDLRD 0 (Sink species)
Hepatic cholesterol esters HCE 10000 mg
Scavenger receptor class B type 1 SRB1 100 (Theoretical value to represent concentration of SRB1 receptors)
Peripheral Tissue Species
Peripheral low density lipoprotein receptors PLDLRs 100 (Theoretical value)
Peripheral low density lipoprotein receptors synthesis PLDLRsS 575.16 (Source species)
Peripheral low density lipoprotein receptors degradation PLDLRD 0 (Sink species)
Peripheral free Cholesterol PFC 57516 mg
Peripheral cholesterol esters PCE 9363 mg
Peripheral steroid synthesis PSS 0 (Sink species)
Peripheral cholesterol synthesis PCS 0(Source species)
Plasma Species
Low density lipoprotein cholesterol LDLC 100 mg/dL
High density lipoprotein cholesterol HDLC 45 mg/dL
Nascent high density lipoprotein NHDL 100 (Theoretical value to represent the initial number of Nascent HDL)
Very low density lipoprotein cholesterol VLDLC 20 mg/dL
Intermediate density lipoprotein cholesterol IDLC 20 mg/dL
Cholesteryl ester transfer protein CETP 100 (Fixed boundary condition)
Lecithin:cholesterol acyltransferase LCAT 100 (Fixed boundary condition)
Hormone sensitive Lipase HSL 100 (Fixed boundary condition)
Lipoprotein Lipase LPL 100 (Fixed boundary condition)
Hepatic Tissue Species and Peripheral Tissue
Species
Cholesterol ester hydrolase CEH 100 (Fixed boundary condition)
acyl coenzyme A: cholesterol acyltransferase ACAT 100 (Fixed boundary condition)

Mc Auley et al.

Mc Auley et al. BMC Systems Biology 2012 6:130   doi:10.1186/1752-0509-6-130

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