Figure 4.

Network diagram of the cholesterol metabolism model. The model is laid out in 6 compartments, 1) intake, 2) intestinal tissue, 3) excretion, 4) plasma, 5) hepatic and 6) peripheral tissue. The arrows represent the flow of cholesterol around the system into its different forms. Enzymes are represented by blue spheres and their catalytic influence on the reaction is indicated by a round arrow head coming into contact with a reaction arrow. Synthesis is represented by the Greek symbol theta, while inhibition is represented by T -shaped arrows. In summary cholesterol from the diet and bile is formed into micelles in the small intestine. Absorbed cholesterol is then transported to the liver where it is exported into the plasma via VLDL. VLDL is in turn catabolised to LDL. Excess cholesterol from peripheral tissue is transferred to the liver via HDL.

Mc Auley et al. BMC Systems Biology 2012 6:130   doi:10.1186/1752-0509-6-130
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