(A-E)The relationship between LDL-C and age. The relationship between LDL-C and age A) for males and B) for females. Graphs A and b were both generated using data from Abbott, Garrison et al. (1983). C) the response of LDL-C in the model to increased cholesterol absorption. D) The response of LDL-C in the model to decreases in the rate of clearance of LDL-C by hepatic LDLRs. E) Parameter scan for khrs (daily rate of synthesis of hepatic cholesterol receptors) and its impact on LDL-C levels.
Mc Auley et al. BMC Systems Biology 2012 6:130 doi:10.1186/1752-0509-6-130