Figure 1 .
Proteomics based network model showing differential expression of proteins in canonical cancer pathways and the intricate involvement of Meq, via hypothesized CD30-NF-κB-Meq pathway. Canonical Network model of proteome data using differential proteomic expression (CD30hi compared to CD30lo) mapped against cancer specific KEGG pathway “Pathways in cancer” and further modified by adding published Meq interaction and hypothesized Meq-CD30-NF-κB-Meq pathway. Light black solid lines indicate direct interaction, dotted lines indicate indirect interaction. Red dotted lines indicate our hypothesized CD30-NF-κB-Meq pathway. Literature based Meq interacting proteins are indicated by dark black lines originating from Meq.
Kumar et al. BMC Systems Biology 2012 6:123 doi:10.1186/1752-0509-6-123