Open Access Highly Accessed Research article

Nuclear Factor kappa B is central to Marek’s Disease herpesvirus induced neoplastic transformation of CD30 expressing lymphocytes in-vivo

Shyamesh Kumar1*, Dusan Kunec2, Joram J Buza3, Hsin-I Chiang4, Huaijun Zhou5, Sugalesini Subramaniam6, Ken Pendarvis7, Hans H Cheng8 and Shane C Burgess78*

Author Affiliations

1 Department of Pathobiology and Population Medicine, Mississippi State University, PO Box 6100, MS, Mississippi State, 39762, USA

2 Institut für Virologie, Freie Universität Berlin, Berlin, Germany

3 School of Life Sciences and Bioengineering, Nelson Mandela African Institute of Science and Technology, PO Box 447, Arusha, Tanzania

4 Department of Bioengineering, University of California-San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA

5 Department of Poultry Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX, 77843, USA

6 Comparative Medicine and Integrative Biology Graduate Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI, 48824, USA

7 College of Agriculture and Life Sciences, University of Arizona, P.O. Box 210036, Tucson, AZ, 85721, USA

8 USDA-ARS, Avian Disease and Oncology Laboratory, 4279 East Mount Hope Road, East Lansing, MI, 48823, USA

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BMC Systems Biology 2012, 6:123  doi:10.1186/1752-0509-6-123

Published: 14 September 2012

Additional files

Additional file 1:

Additional file 1 contains four worksheets, sheet 1 (CD30hiVs. CD30loprotein expression): contains proteins identified from CD30loand CD30hicells, worksheet 2 (ChIP identified proteins): contains proteins identified in ChIP experiment. Worksheet 3 (NF κB isoforms subcellular locations): contains actual numbers of peptides of different isoforms of NF-κB in nuclear and extranuclear fractions, and worksheet 4 (Phosphorylated peptides locations) contains actual numbers of phosphorylated and non-phosphorylated peptides identified. (XLS 1901 kb)

Format: XLS Size: 1.9MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 2:

Additional file 2 contains three worksheets, sheet 1 contains the results from the statistical analysis of microarray data, sheet 2 contains expression data for only miRNAs and sheet 3 contains predicted targets genes and the relative protein expression of the targets of the miRNAs. (XLS 8422 kb)

Format: XLS Size: 8.2MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 3:

Additional file 3 contains mRNA and protein expression fold changes in terms of CD30hiover CD30locells. (XLS 859 kb)

Format: XLS Size: 860KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 4:

Additional file 4 contains pentile wise Meq binding sites for 88 concordantly expressed host host gene products. (XLS 30 kb)

Format: XLS Size: 30KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data