Open Access Highly Accessed Methodology article

Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism

Susanna Bazzani*, Andreas Hoppe* and Hermann-Georg Holzhütter

Author Affiliations

Institut für Biochemie, Charite-Universitätsmedizin, Reinickendorfer Str. 61, Haus 10, 13347 Berlin

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BMC Systems Biology 2012, 6:118  doi:10.1186/1752-0509-6-118

Published: 31 August 2012

Additional files

Additional file 1:

Merged set of validated antimalarial targets.

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Additional file 2:

Updated version of PlasmoNet. The network is available on Biomodels database under the ID MODEL1206070000.

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Additional file 3:

HepatoNet1 applied metabolic objectives.

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Additional file 4:

PlasmoNet applied metabolic objectives.

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Additional file 5:

Appendix A. Flux minimization optimization framework.

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Additional file 6:

Appendix B. Reduced Fitness optimization framework and example.

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