Figure 2.

Calculation of efficiency measure. A. Illustration of oxygen ( <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M23','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M23">View MathML</a>) and total substrate uptake rates (vs) for exclusive utilization of glucose (▲), oleate (+), acetoacetate (●) and lactate (◼). Calculated distances for each criterion were visualized for acetoacetate, with dotted lines indicating distances to minimal and maximal oxygen uptake rate and straight lines to respective minimal and maximal total substrate uptake rates. Additional markers indicate theoretical values for best (green circle) and worst (red circle) solution. The efficiency index <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M24','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M24">View MathML</a> is defined as the relative distance for each solution to the best-case solution: <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M25','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M25">View MathML</a>. B. Bar plots for comparison of calculated efficiency indices for simulated substrate compositions to experimental results [70].

Karlstädt et al. BMC Systems Biology 2012 6:114   doi:10.1186/1752-0509-6-114
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