Figure 1.

Illustration of total substrate uptake rate (vs) and oxygen demand (<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M12','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M12">View MathML</a>) for a fixed glucose supply with (A) β = 0.25 and (B) β = 0.75. The ATP consumption rate (vATPase) were restricted to 21.6 <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M13','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M13">View MathML</a>. The panels A.1 and B.1 refer to the oxygen demand ( <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M14','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M14">View MathML</a>) for the given glucose proportion, while panels A.2 and B.2 refer to the total substrate uptake rate (vs). For each panel we marked the optimal substrate composition (*): (A) vGlucose = 25%, vOleate = 64%, vAcetoacetate = 0%, vLactate = 11%, (B) vGlucose = 75%, vOleate = 25%, vAcetoacetate = 0%, vLactate = 0%.

Karlstädt et al. BMC Systems Biology 2012 6:114   doi:10.1186/1752-0509-6-114
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