Mesoscale Attributes. Top: number of detected modules Nc as a function of the normalized rescaling parameter r. The mesoscale has been screened only for a range of r yielding an interpretable amount of modules. DU and DS topologies show more than one persistent mesoscopic plateau, whereas the UU topology only has a single plateau made up of around Nc ≈ 200 communities. Beyond r = 0.5, no other stable plateau can be found for this topology. Bottom: the detected community structures for the three versions of the TRN of M. tuberculosis are compared to the functional partitions in Tuberculist . DS is the only network that shows significant values of similarity, in terms of the Asymmetric Wallace Index, against the functional partition for a large range of r values.
Sanz et al. BMC Systems Biology 2012 6:110 doi:10.1186/1752-0509-6-110