Glycolytic oscillations in the wild type BY4743 compared to isogenic mutants in genes encoding respective components of the cAMP signal transduction pathway: BY4743 (blue trace);pde2Δ (red trace),ira2Δ (green trace). Oscillations were induced by the addition of glucose to a concentration of 30 mM after 60 seconds, followed by addition of KCN to a final concentration of 5 mM after 140 seconds. NADH fluorescence intensity was followed using a fluorimeter.
Williamson et al. BMC Systems Biology 2012 6:108 doi:10.1186/1752-0509-6-108