Open Access Methodology article

Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling

Matthew S Creamer12, Edward C Stites1, Meraj Aziz1, James A Cahill2, Chin Wee Tan3, Michael E Berens4, Haiyong Han1, Kimberley J Bussey1, Daniel D Von Hoff1, William S Hlavacek156 and Richard G Posner12*

Author Affiliations

1 Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA

2 Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA

3 Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia

4 Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA

5 Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA

6 Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA

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BMC Systems Biology 2012, 6:107  doi:10.1186/1752-0509-6-107

Published: 22 August 2012

Additional files

Additional file 1:

ErbB_model.bngl. This plain-text file is a BioNetGen input file. It contains a specification of the model structure as well as nominal parameter values. (BNGL 123 kb)

Format: BNGL Size: 124KB Download file

Open Data

Additional file 2: This archive file provides a copy of the files available online ( These files serve to annotate the model. (ZIP 759 kb)

Format: ZIP Size: 760KB Download file

Open Data