Table 1

Gene Ontology (GO) terms enriched with module genes (GO level ≥ 4)

GO terms

Observed*

P

PBH$


Biological process

GO:0007268: synaptic transmission

45

7.18 × 10-38

1.18 × 10-34

GO:0007267: cell-cell signaling

56

8.78 × 10-37

7.21 × 10-34

GO:0019226: transmission of nerve impulse

46

2.84 × 10-36

1.55 × 10-33

GO:0044057: regulation of system process

36

1.23 × 10-29

2.89 × 10-27

GO:0051239: regulation of multicellular organismal process

55

1.07 × 10-29

2.89 × 10-27

GO:0050877: neurological system process

59

4.72 × 10-26

9.69 × 10-24

GO:0007154: cell communication

103

6.14 × 10-26

1.12 × 10-23

Molecular function

GO:0008227: G-protein coupled amine receptor activity

15

5.13 × 10-21

7.18 × 10-19

GO:0035240: dopamine binding

7

2.25 × 10-13

1.58 × 10-11

GO:0005230: extracellular ligand-gated ion channel activity

12

4.17 × 10-12

2.34 × 10-10

GO:0004888: transmembrane receptor activity

40

6.55 × 10-12

2.78 × 10-10

GO:0005102: receptor binding

31

9.87 × 10-11

3.07 × 10-9

GO:0022834: ligand-gated channel activity

13

2.46 × 10-10

5.74 × 10-9

Cellular component

GO:0043005: neuron projection

30

2.43 × 10-22

3.91 × 10-20

GO:0044459: plasma membrane part

61

3.12 × 10-20

2.51 × 10-18

GO:0000267: cell fraction

45

1.45 × 10-19

7.78 × 10-18

GO:0005887: integral to plasma membrane

47

5.84 × 10-19

2.35 × 10-17

GO:0031226: intrinsic to plasma membrane

47

1.27 × 10-18

4.09 × 10-17

GO:0042995: cell projection

35

5.50 × 10-18

1.48 × 10-16

GO:0005886: plasma membrane

80

1.64 × 10-17

3.77 × 10-16

GO:0030424: axon

18

1.15 × 10-15

2.31 × 10-14

GO:0030425: dendrite

17

2.76 × 10-14

4.94 × 10-13

GO:0005626: insoluble fraction

32

7.11 × 10-13

1.14 × 10-11


*Number of the observed DEPgenes in the category.

$P values were adjusted by Benjamini & Hochberg (BH) method [34].

Jia et al. BMC Systems Biology 2011 5(Suppl 3):S12   doi:10.1186/1752-0509-5-S3-S12

Open Data